WASHINGTON (Reuters) – A longstanding practice of giving steroids to patients during cardiopulmonary bypass surgery to reduce inflammation failed to help patients and actually increased the risk of heart attacks, according to results of a large clinical trial.
“This study shows that administering steroids during cardiac surgery requiring bypass can cause harm,” said Dr. Richard Whitlock, a cardiologist with McMaster University in Hamilton, Ontario, who led the international trial. “Based on these results, we suggest that steroids should not be used prophylactically during cardiac surgeries that require the use of cardiopulmonary bypass.”
WASHINGTON, March 31 (Reuters) – Bariatric weight loss
surgery on obese patients with type 2 diabetes helped many to
get their blood sugar to healthy levels and to no longer require
any diabetes medicines, including insulin, three years after the
procedure, according to data presented at a major medical
meeting on Monday.
The surgery also helped patients reduce the need for high
blood pressure and cholesterol medicines and led to quality of
life improvements compared with those who received medical
weight-loss therapy, researchers found.
WASHINGTON (Reuters) – A non-surgically implanted heart valve meant to delay open heart surgery in children with congenital heart defects worked well for all but a few patients during a year of follow-up observation, in line with favorable results seen in original clinical trials of the Medtronic Inc product.
The Melody transcatheter pulmonary valve was approved in 2010 under a U.S. humanitarian device exemption, which allowed it on the market as long as a follow-up study was conducted to assess the product’s reliability and safety. The valve is guided to the heart by a catheter, a minimally invasive procedure.
WASHINGTON (Reuters) – A new type of heart drug being developed by GlaxoSmithKline, which failed the main goal of a Phase III study of patients with chronic but well-treated heart disease, showed signs of potential benefit, the trial’s co-leader said.
The results presented at the American College of Cardiology scientific meeting in Washington on Sunday provided a glimmer of hope that the medicine, darapladib, may have value.
WASHINGTON, March 30 (Reuters) – A non-surgically implanted
heart valve meant to delay open heart surgery in children with
congenital heart defects worked well for all but a few patients
during a year of follow-up observation, in line with favorable
results seen in original clinical trials of the Medtronic Inc
The Melody transcatheter pulmonary valve was approved in
2010 under a U.S. humanitarian device exemption, which allowed
it on the market as long as a follow-up study was conducted to
assess the product’s reliability and safety. The valve is guided
to the heart by a catheter, a minimally invasive procedure, and
patients typically go home after only one night in the hospital.
WASHINGTON, March 30 (Reuters) – The minimally invasive
aortic heart valve replacement system from Edwards Lifesciences
Corp performed better than a rival product sold by
Medtronic Inc in the first head-to-head study of the
two, according to data from a small German trial presented at a
major heart meeting on Sunday.
The results are unlikely to be seen as decisive given the
size and limited scope of the study. But they could provide the
Edwards sales force with a valuable marketing tool as the two
companies vie for market share with their competing
transcatheter aortic valve replacement (TAVR) systems.
WASHINGTON (Reuters) – Amgen Inc’s drug from a high profile new class of experimental medicines lowered “bad” LDL cholesterol by 55 percent to 66 percent compared with a placebo in a trio of late-stage clinical trials, according to data presented on Saturday.
Amgen had previously said the drug, evolocumab, met the main goals of five late-stage trials involving some 4,000 patients by significantly outperforming placebo or another cholesterol medicine in a variety of patient populations.
PROVIDENCE, RI/WASHINGTON, March 29 (Reuters) – Patients
treated by renal artery denervation were no more likely to see
their blood pressure decline than those who received a fake
therapy in a major clinical trial, calling into question a
therapy used in more than 80 countries to treat hypertension
that doesn’t respond to drugs.
The study was considered a key test of the intervention in
which nerve connections between the heart and kidney were
disrupted in an effort to lower blood pressure as prior trials
did not include a blinded control group for efficacy comparison.
WASHINGTON (Reuters) – Switching over to daylight saving time, and losing one hour of sleep, raised the risk of having a heart attack the following Monday by 25 percent, compared to other Mondays during the year, according to a new U.S. study released on Saturday.
By contrast, heart attack risk fell 21 percent later in the year, on the Tuesday after the clock was returned to standard time, and people got an extra hour’s sleep.
WASHINGTON, March 29 (Reuters) – Medtronic Inc’s
minimally invasive CoreValve system for replacing diseased
aortic heart valves led to a significantly higher survival rate
after one year than traditional open heart surgery in patients
deemed at high risk of death during surgery, according to data
from a study presented on Saturday.
One year after receiving the CoreValve in the 795-patient
Phase III trial, the rate of death was 14.2 percent compared
with a 19.1 percent death rate in the surgery group, researchers
said. The result, presented at the American College of
Cardiology scientific meeting in Washington, was deemed to be