With Zika, ethical and medical questions — and few answers

February 2, 2016
A pregnant woman waits to be attended to at the Women's National Hospital in San Salvador, El Salvador January 29, 2016. El Salvador on January 21 urged women in the Central American nation to avoid getting pregnant until 2018 to avoid their children developing birth defects from the mosquito-borne Zika virus which has rampaged through the Americas. REUTERS/Jose Cabezas - RTX24MYV

A pregnant woman waits to be attended to at the Women’s National Hospital in San Salvador, El Salvador January 29, 2016. REUTERS/Jose Cabezas

On Jan. 23, as the cleanup from Winter Storm Jonas began outside of my apartment on the Upper West Side of Manhattan, a patient posed a seemingly straightforward question to me: Should I cancel my upcoming trip to Florida? This woman was concerned about potentially contracting the Zika virus — a mosquito-borne illness known to cause fever, rash, joint paints, and, it appears, a devastating birth defect called microcephaly.

In theory, I was the right person to ask. I’m an infectious disease specialist at NewYork-Presbyterian Hospital and my research focuses on the ethical implications of medical decision-making. But this case was tricky because the patient was in her first trimester of pregnancy, and more importantly, she happened to be my wife.

“Is it worth it?” she asked, as she curled up next to me on the couch.

Like most doctors in the United States, my experience with the Zika virus is minimal. It occasionally gets discussed on rounds when we see an unexplained fever in a patient returning from the Caribbean, but that’s about it. In those cases — the ones not involving a pregnant woman — the stakes are relatively low. The symptoms, like body aches and bloodshot eyes, are annoying, but they don’t carry any long-lasting effects.

This latest Zika outbreak is uniquely terrifying because of the rapid spread of the virus — the World Health Organization said it has “explosive pandemic potential” — and because of the imagery: every Google search leads to a picture of a concerned mother holding an infant with an uncomfortably tiny head. That’s the telltale sign of microcephaly, which can lead to seizures, developmental delay, and a shortened life expectancy. So what do we do about it? And how do we decide where to travel?

Zika is problematic from a public health perspective because it leads to something harmless or disastrous, and that presents a unique ethical quandary for doctors and patients. When does a potential exposure to a possible teratogen become unacceptable? What degree of diagnostic uncertainty are we comfortable with? Almost every day I’m asked about Zika and my level of concern seems to change with the news cycle. I’ve also found that my professional notions of risk and volition are viewed differently through the lens of fatherhood. In some ways, my travel advice to my wife felt like my first act as a parent to our unborn daughter.

The virus has spread through more than twenty countries in the Americas, where contraceptive access is often limited and abortion laws are some of the most restrictive in the world. Some countries in the region, like El Salvador, have chosen to err far on the side of caution, recommending that no one in the country get pregnant until 2018. (Good luck with that.) Others, like Brazil, Colombia, and Ecuador, have also urged women to avoid getting pregnant, but haven’t put forth a timetable for this unprecedented recommendation. Still others in the region, like Haiti and Martinique, have not provided any guidelines. This patchwork approach has led to confusion, especially as the virus migrates north.

The Centers for Disease Control and Prevention have issued a travel alert for pregnant women, suggesting they postpone travel to the areas where Zika virus transmission is ongoing. Unfortunately, the situation on the ground is changing so rapidly that it can be difficult to determine exactly where that is. Jamaica reported its first case on Saturday and many experts (myself included) believe it will spread throughout the United States over the next few months. (Dozens of Americans in eleven states and Washington, D.C., have already contracted the virus.)

Adding to the confusion, Zika virus often causes minimal (or no) symptoms in infected patients. Pregnant mothers don’t need to have symptoms to transmit the virus to their fetus, and there’s no reliable test, treatment or vaccine to combat the disease. In short, we’re all playing a bit of a guessing game when we advise patients on travel, especially to places where the virus isn’t yet circulating.

Taking all of this into consideration, I found the fundamental principles of moral decision-making — things like autonomy, proportionality, and beneficence — to be confusing and unhelpful as I tried to answer my wife’s question. On one hand, it seemed unwise to travel anywhere. The risk of microcephaly for my unborn child was far too great to justify any avoidable trip. On the other hand, I don’t want to live my life in fear. I’ve looked at the data and read the recommendations. So why not follow the evidence? Zika isn’t circulating widely in Florida, so why not go?

Across the country, patients are being told to consult their doctor when they have questions about Zika. But as my wife (also a doctor) quickly discovered, physicians don’t entirely know what to recommend. The CDC has created an algorithm for testing pregnant women who may have been exposed to the virus, but it’s exceedingly complicated and, more troublingly, it may lead to the detection of microcephaly outside of the window of possible pregnancy termination. You might learn of a birth defect when it’s too late to do anything about it.

One of the more intriguing ethical issues that hasn’t been discussed involves adoption, particularly for parents who are planning to adopt a child from a country now affected by the outbreak. Should they view their roles any differently? Or attempt to intervene on behalf of their fetus? A generation of unborn children are suddenly at risk, and the ripple effect will extend far beyond the borders of the affected nations.

After much deliberation, my wife and I decided to take the trip to Florida. She wore long-sleeves and tried to avoid mosquitos, and as we walked in the sun, it felt like the right decision. But after one of our walks, I received a text from an old friend — an obstetrician who specializes in fertility. She was writing to congratulate us on our pregnancy and told us to avoid unnecessary travel, especially to places like Florida.

On Feb. 1, the World Health Organization declared the Zika outbreak a “public health emergency of international concern.” The designation fast-tracks aid and research to tackle the virus and puts it in the same category of concern as the Ebola virus. It also gives WHO decisions the force of international law. But at this point, even with growing attention, we’re left with more questions about Zika than answers. I still don’t know if the trip to Florida was misguided.

At times, Zika can feel far away — especially if you live in a place where mosquitos are uncommon. But the ethical questions surrounding the outbreak touch us all. There is now a groundswell of support in the medical community to wipeout the species of mosquito that carries the Zika virus, and, potentially, to bring back DDT to do it. Is this the right move?

The foundation of modern bioethics mandates a duty to protect, and in this case, it’s unborn children who need our help. As this story continues to evolve, we must ask ourselves: Are we doing enough to protect them?

2 comments

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If anything keeps population explosion under control, that’s a good thing. Zika only has the advantage because of the millions of hosts in overcrowded slums.

Posted by GetReel | Report as abusive

Wiping out an entire species of Mosquito is an insane approach. Before any action is taken we tend to look at the positives and negatives resulting from that action. we can all see the the target positive of no more mosquitos left to spread Zika. The alarming part though is those who would claim to be able to list all of the negatives. No doubt at least one or two scientists will step forward with expertise ad nauseum in some narrow field, and claim that they know all of the side effects of wiping out a species. No one knows all of the side effects of taking such an action! What if there are unintended consequences to pollinators? (Think accelerated colony collapse disorder. What if such widespread use of DDT poisons our groundwater? I am not a scientist, and my what if questions may be way off target, but my tendency to question is right on the mark. The world is not a bunch of piecewise disjoint objects where you can just remove things without consequence. This much I know.

Posted by CanyonLiveOak | Report as abusive