CHICAGO (Reuters) – An experimental Johnson & Johnson vaccine completely prevented HIV infection in half of monkeys that got the shot and then were exposed to high doses of an aggressive virus, results that spurred the company to test the vaccine in people, academic and company researchers said on Thursday.
The international trial is underway in 400 healthy volunteers in the United States, East Africa, South Africa and Thailand. It is the first time since Merck’s failed 2007 trial that a major pharmaceutical company has sponsored clinical development of an HIV vaccine, said Dr. Dan Barouch, a vaccine researcher at Beth Israel Deaconess Medical Center and the Ragon Institute of Massachusetts General Hosptial, MIT and Harvard.
CHICAGO (Reuters) – The much-anticipated results of a study of DNA taken from the hand bone of the so-called Kennewick Man, a 8,500-year-old skeleton discovered in Washington state in 1996, suggest the man was most closely related to Native American populations, a team of international researchers said on Thursday.
The DNA findings, published online in the journal Nature, contradict a 2014 study based on anatomical data that suggested the skeleton was most closely related to Polynesian or indigenous Japanese populations.
CHICAGO (Reuters) – The medical view of cancer is in transition, as cancer doctors increasingly focus on the defective genes that are driving the disease rather than the organ in which it takes root.
Oncologists hope that by understanding the genetic underpinnings of cancer rather than focusing on whether it originated in the breast or the liver, they will be able to give patients better, more personalized and more effective treatments.
CHICAGO, June 2 (Reuters) – The medical view of cancer is in
transition, as cancer doctors increasingly focus on the
defective genes that are driving the disease rather than the
organ in which it takes root.
Oncologists hope that by understanding the genetic
underpinnings of cancer rather than focusing on whether it
originated in the breast or the liver, they will be able to give
patients better, more personalized and more effective
CHICAGO, June 1 (Reuters) – The National Cancer Institute in
July will start enrolling patients in a clinical trial seeking
to match the underlying genetic defect driving a person’s tumor
with one or more of 20 approved or experimental drugs targeting
The announcement, made at the American Society for Clinical
Oncology meeting on Monday, is meant to use approved or
experimental drugs to develop insights that will ultimately
enable doctors to prescribe drugs based on the molecular cause
of the cancer, rather than the organ in which it was originally
CHICAGO (Reuters) – Patients with colon and other cancers who have a specific defect in genes needed for DNA repair are far more likely to respond to a new class of drugs such as Merck & Co’s Keytruda, which enlist the immune system to attack tumors, a new study has shown.
The small study, financed not by Big Pharma but by swimmers who raised charitable donations, tested Keytruda in patients with advanced colon and rectal cancers and found 92 percent of patients with the genetic defect had their disease controlled compared with 16 percent who did not carry the defect.
CHICAGO, May 27 (Reuters) – A group of international
researchers is making the case that genetic tests that look for
multiple hereditary genes suspected of being linked to breast
cancer should not be offered until they are proven to be valid
and useful in clinical practice.
Such tests, made by several companies including Myriad
Genetics Inc, Ambry Genetics, Invitae and
Illumina Inc, cover up to 100 inherited cancer genes,
including more than 20 for breast cancer.
CHICAGO (Reuters) – Genome pioneer J. Craig Venter’s company has signed a broad collaboration agreement with the Cleveland Clinic to sequence and analyze de-identified blood samples from the health system’s patients, the two parties said on Thursday.
The two organizations will apply whole genome, cancer and microbiome sequencing with the goal of discovering new disease genes and disease pathways associated with heart disease.
CHICAGO, May 14 (Reuters) – U.S. cases of two deadly types
of foodborne pathogens have fallen sharply since 2008, but rates
of other key types of foodborne bugs have increased, according
to the latest report on nine pathogens tracked by health
“The picture is mixed,” said Dr. Patricia Griffin of the
U.S. Centers for Disease Control and Prevention’s division of
foodborne diseases, adding, “Most of it is not good news.”
CHICAGO, May 13 (Reuters) – A personalized treatment
targeting a patient’s individual genetic makeup helped cure more
children with a rare form of kidney cancer, researchers said on
The findings, based on two studies led by Dr. David Dix of
the British Columbia Children’s Hospital in Vancouver, were
released ahead of the American College of Clinical Oncology
meeting later this month.