Two of the biggest and most influential U.S. conservative groups have split over U.S. Supreme Court nominee Sonia Sotomayor.

USA-COURTS/SOTOMAYORThe U.S. Chamber of Commerce, with more than three million business members, urged the U.S. Senate to confirm her. It concluded that the New York judge would provide the court with a needed perspective on business matters.

But the National Rifle Association, with four million members, opposed President Barack Obama’s nominee. They wrote that they see Sotomayor as a threat to gun rights.

The Senate seems virtually certain to confirm Sotomayor — before it begins its August recess — as the first Hispanic and just third woman ever on the highest U.S. court.

In a letter to the Senate Judiciary Committee, which held Sotomayor’s confirmation hearing last week, Bruce Josten, executive vice president at the Chamber, hailed the former courtroom lawyer turned appeals judge.